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For years, bleeding complications in patients undergoing transcatheter procedures, predominantly percutaneous coronary interventions (PCIs), were not included in the primary outcome of clinical trials. It was not until the REPLACE-2 (Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events 2) trial, which assessed two anticoagulant strategies for PCI, that bleeding became a component of the primary outcome and was found to be a predictor of death at 1 year that was as powerful as myocardial infarction.1 As the population ages, increasing numbers of patients have indications for oral anticoagulants, either a vitamin K antagonist or direct-acting oral anticoagulants. Not . . .
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March 29, 2020 at 08:00PM
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How Un-POPular Is Bleeding in Patients with TAVI? - nejm.org
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